Experimental approaches to endometrial and ovarian cancer.
نویسنده
چکیده
THE most well-known types of hormone-dependent tumours are those of breast, endometrium and prostate, but several other types probably exist (Crowley, 1969; Crowley & Duwe, 1969). Because of their special nature they are open to endocrine manipulation in ways not possible in other tumours. Tumours of the ovary are not easily characterized in this respect as there are so many types and several are apparently quite insensitive to hormone therapy. There have been very many studies on the effects of endocrine surgery and therapy in carcinoma of the breast (e.g. Forrest & Kunkler, 1968), but on the whole little real success has been shown. One factor in this lack of success is the great differences in the characteristics of the various cell types in breast tissue. In contrast, endometrium, though not of one pure cell type, is much less complex and valuable results can be obtained with endocrine therapy. It has been clearly established that oestrogen has a growth-promoting effect on endometrial carcinoma (Gusberg, 1967, 1973) and that high doses of suitable progestagens have an inhibitory effect on tumour growth in many cases (Kelley & Baker, 1961; Varga & Henriksen, 1961; Kennedy, 1963). These effects are more marked in well-differentiated adenocarcinoma and are of little importance in undifferentiated tumours (Kennedy, 1963; Liggins, 1964; Varga & Henriksen, 1965). Although it has long been thought that oestrogen may act as a carcinogen in the endometrium in certain circumstances, the balance of opinion now supports the view that natural oestrogens are not carcinogenic. The position of synthetic oestrogens such as stilboestrol is at present somewhat equivocal. Certain aspects of this problem are reviewed by Brush (1973). Some ovarian tumours produce quite large amounts of hormones, some secrete only traces and others are quite inactive. The variations in morphology and behaviour are very great. Certain types are benign, but malignant tumours with a very poor prognosis are common. Ovarian carcinoma is normally treated by the conventional approaches of surgery, radiotherapy and chemotherapy. In view of the poor results obtained it might be useful to explore the possiblity of using endocrine therapy, in conjunction with the conventional treatments.
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ورودعنوان ژورنال:
- Postgraduate medical journal
دوره 49 568 شماره
صفحات -
تاریخ انتشار 1973